CJC-1295 is a growth hormone releasing peptide that has been studied for its ability to stimulate the pituitary gland and increase circulating levels of growth hormone and insulin-like growth factor 1 (IGF-1). When combined with other peptides such as ipamorelin, the duo can produce synergistic effects on muscle hypertrophy, fat loss, recovery, and overall well-being. Understanding how much CJC-1295 to pair with ipamorelin requires a look at dosage ranges, timing, and the broader context of peptide stacks that are tailored for specific goals like performance enhancement or longevity.



Peptide Stacks: Safe, High-Impact Combinations for Performance, Longevity & Every Goal



A peptide stack is essentially a carefully curated set of peptides that work together to hit multiple physiological targets. The purpose of stacking rather than using a single compound is to achieve a more balanced hormonal milieu and reduce the risk of side effects associated with high doses of a lone peptide. When you design a stack, you consider factors such as:





Targeted outcomes: muscle growth, fat loss, improved sleep, enhanced recovery, anti-aging benefits, or neurological support.


Synergistic mechanisms: peptides that stimulate different aspects of the endocrine system (e.g., GH secretagogues, IGF-1 boosters, and neuropeptide modulators).


Safety profile: doses that are below thresholds for adverse effects, often guided by clinical data or anecdotal evidence from experienced users.



By layering peptides thoughtfully, you can keep each component at a lower dose while still achieving strong results. For instance, pairing CJC-1295 with ipamorelin and adding a recovery peptide such as BPC-157 creates a stack that stimulates growth hormone release, enhances protein synthesis, and accelerates tissue repair—all at safe individual doses.

What Are Peptide Stacks?



Peptide stacks are essentially "cocktails" of biologically active peptides. Unlike traditional drugs that often target one receptor or pathway, peptides can influence multiple signaling cascades. A typical stack may include:





Growth hormone secretagogues (e.g., CJC-1295, ipamorelin, GHRP-2) to elevate GH and IGF-1.


Receptor agonists/antagonists that fine-tune the body’s response to hormones (for example, melanotan II for skin pigmentation or PT-141 for sexual function).


Repair peptides such as BPC-157 and TB-500 which accelerate wound healing and tendon repair.


Neuroprotective peptides like Selank or Semax that improve cognition and reduce anxiety.



The stack’s design hinges on the principle of "less is more": by keeping each peptide’s dose modest, you mitigate the risk of hormonal imbalance while still reaping the benefits of combined action. The overall effect can be greater than the sum of its parts, especially when peptides target complementary pathways—such as GH stimulation coupled with direct tissue repair.

Wolverine Stack (Recovery & Repair): BPC-157 + TB-500



For athletes or individuals who push their bodies hard, recovery is as important as training. The Wolverine Stack is a popular combination that pairs two of the most well-researched repair peptides:





BPC-157 – A fragment derived from body protective compound (BPC). It promotes angiogenesis (formation of new blood vessels), enhances collagen production, and accelerates tendon and ligament healing. Typical dosing ranges from 200–500 micrograms per day, divided into two or three injections.



TB-500 – A synthetic version of thymosin beta-4 that encourages cell migration and reduces inflammation. TB-500 is often dosed at 2–5 milligrams per week, split into a few injections over the course of the week.



When used together, BPC-157 and TB-500 can significantly reduce recovery time after intense training sessions or injury. They also work synergistically to increase tissue resilience and mitigate the risk of chronic inflammation. Many users incorporate this stack during periods of heavy workload or after surgery, tapering doses as they approach full recovery.

How Much CJC-1295 with Ipamorelin Should You Take?



When pairing CJC-1295 (often in its long-acting formulation, CJC-1295 with DAC) with ipamorelin, the goal is to stimulate GH release without overloading the system. Here’s a guideline that balances effectiveness and safety:





Initial Dose (Beginner Phase)


- CJC-1295: 100–200 micrograms per injection, once daily or twice daily.

- Ipamorelin: 10–20 micrograms per injection, paired with CJC-1295 in the same injection or given immediately after.




This phase allows your body to acclimate to the peptides and monitors for any adverse reactions such as water retention, headaches, or joint pain.





Maintenance Dose (Intermediate Phase)


- CJC-1295: 200–300 micrograms per day, divided into two injections (morning and evening).

- Ipamorelin: 20–30 micrograms per injection, timed to coincide with each CJC-1295 dose.




At this level, you’ll typically see a noticeable increase in lean muscle mass, improved recovery, and a modest reduction in body fat.





Advanced Dose (Optimized Phase)


- CJC-1295: 300–400 micrograms per day, split into two injections.

- Ipamorelin: 30–40 micrograms per injection, paired with each CJC-1295 dose.




This is the upper end of a safe range for most users, often employed during cutting cycles or when maximum anabolic stimulus is desired.



Timing Tips





Morning Injection: Taking the first dose upon waking helps align peptide release with natural circadian rhythms, which naturally peak GH secretion in the early morning.


Pre-Workout or Pre-Sleep: The second injection can be taken before a workout to aid muscle repair and growth, or before bed to support overnight hormone synthesis.



Stacking With Recovery Peptides

If you are also using the Wolverine Stack (BPC-157 + TB-500), consider spacing the recovery peptides away from the GH secretagogues. A typical schedule might involve:





CJC-1295 + Ipamorelin: Morning and evening injections.


BPC-157/TB-500: Once or twice per week, on non-training days to avoid overlap of anabolic and repair signals.



Monitoring & Adjustments

Keep a log of your daily doses, workout intensity, sleep quality, and any side effects. If you notice excessive water retention, headaches, or joint discomfort, reduce the ipamorelin dose first—since it is more potent at stimulating GH per microgram. Adjusting CJC-1295 downward can also help if you’re experiencing hormonal imbalance.



Safety Considerations





Blood Sugar: Growth hormone can influence glucose metabolism; monitor blood sugar levels if you have diabetes or prediabetes.


Hormonal Balance: Long-term use may suppress natural GH production; periodic breaks (e.g., 4–6 weeks off after a cycle) are recommended to allow the endocrine system to reset.


Source Quality: Ensure peptides come from reputable suppliers with third-party testing to avoid contamination or incorrect dosages.



By following these guidelines, you can harness the synergistic power of CJC-1295 and ipamorelin while maintaining a safe approach that respects your body’s natural limits. The key is incremental dosing, consistent monitoring, and thoughtful stacking with recovery peptides like BPC-157 and TB-500 for optimal performance and longevity.