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Although testosterone may make prostate cancer grow, it is not clear that testosterone treatment actually causes cancer. Men taking testosterone replacement must be carefully monitored for prostate cancer. There are times when low testosterone is not such a bad thing. For example, problem with function of pituitary gland or adrenal glands may lead to reduced testosterone production. As surprising as it may be, women can also be bothered by symptoms of testosterone deficiency. Some men who have a testosterone deficiency have symptoms or conditions related to their low testosterone that will improve when they take testosterone replacement. The testes produces less testosterone, there are fewer signals from the pituitary telling the testes to make testosterone.
Pubertal effects begin to occur when androgen has been higher than normal adult female levels for months or years. For postnatal effects in both males and females, these are mostly dependent on the levels and duration of circulating free testosterone. It is possible to have low testosterone without symptoms, and it is normal for testosterone levels to decrease gradually with age.3
Test subjects with an artificially enhanced testosterone level generally made better, fairer offers than those who received placebos, thus reducing the risk of a rejection of their offer to a minimum. In humans, testosterone appears more to promote status-seeking and social dominance than simply increasing physical aggression. Thus the link between testosterone and aggression and violence is due to these being rewarded with social status. This could explain why some studies find a link between testosterone and pro-social behaviour, if pro-social behaviour is rewarded with social status.
Weight changes during TRT are often part of a larger process of improving overall health and hormone balance. For some individuals, sudden weight gain might lead to frustration or self-consciousness. While many people on TRT expect to build muscle and lose fat, this doesn’t happen automatically. Some people on TRT report feeling hungrier than usual, which may lead to overeating and fat gain if not managed properly.
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