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Share that you are seeking evaluation and treatment. Alternatively, you may have a co-occurring condition like depression or anxiety that requires additional treatment. Your injection frequency may be creating fluctuating levels.
I see TRT in the same light as I other medical procedures, such as a bariatric, or open heart surgery. This includes addressing the expectations and motivations behind seeking treatment, as well as the potential impact of TRT on self-esteem and self-image. More severe complications, such as an increased risk of cardiovascular events or prostate issues, require careful monitoring by healthcare professionals. Common side effects may include acne, fluid retention, and changes in blood pressure. While this does not suggest that testosterone directly causes aggression, it highlights its role in modulating aggressive responses.(Dabbs, et al., 1997).
It directly influences how the brain processes stress, manages frustration, and maintains emotional balance. Hopefully this answers the question, can testosterone cause aggression, anger, and anxiety? However just like synthetics cause more anabolic effects, higher levels of testosterone cypionate can do this too. Most of the testosterone used for bodybuilding are synthetic forms of testosterone.
1st Optimal does not provide testosterone care for individuals seeking treatment solely for muscle building or aesthetic purposes (i.e., bodybuilding). 1st Optimal is a telehealth platform designed for both men and women, offering personalized medical care and lifestyle enhancements. Most patients begin noticing improvements in energy, mood, and sleep within 2-4 weeks of starting treatment. 1st Optimal uses bioidentical hormones exclusively in our treatment protocols. Bioidentical hormones are structurally identical to the hormones your body naturally produces, while traditional (synthetic) hormones have a different molecular structure.
A 2020 study in Endocrine Reviews confirmed that chronic cortisol elevation suppresses gonadal hormone production in both men and women. Cortisol dysregulation, where cortisol stays elevated at night instead of declining, is another hormonal driver of poor sleep quality. Studies show that testosterone therapy for women with documented deficiency can meaningfully improve sexual function. Sexual desire in women depends on a balance of estrogen, testosterone, and DHEA. Fatigue is one of the most reported hormone imbalance symptoms in women. Declining estrogen levels disrupt your body’s thermoregulation. When these hormones fall out of optimal range, the effects ripple across multiple body systems.
Hone is an online clinic that helps men and women manage their health. You can test your levels with an at-home kit or a blood test. You could fill a whole refrigerator with the variety of hormone-healthy foods you can add to your plate. Hone’s at-home hormone assessment can determine if you qualify for treatment.
Research-backed tools, tactics, and techniques to maximize your health, delivered to your inbox every Monday. Dr. James R. Staheli is the Medical Director for Broad Health, Hone Health’s affiliated medical practice and a family medicine doctor in Atlanta, Georgia. Contact us at if you see an error. Every article is rigorously reviewed by medical experts to ensure accuracy. We source research from peer-reviewed medical journals, top government agencies, leading academic institutions, and respected advocacy groups. The Edge upholds the highest standards of health journalism.
Many men with low testosterone also have undiagnosed sleep apnea. Sleep apnea suppresses testosterone production while also directly causing fatigue, irritability, and cognitive difficulties. Both hypothyroidism (low thyroid) and hyperthyroidism (high thyroid) can cause irritability, mood swings, and fatigue. While testosterone imbalance is a common and underrecognized cause of irritability in men, other conditions must be considered in a comprehensive evaluation.
For men with low blood testosterone levels and symptoms most likely caused by a low level, the benefits of hormone replacement therapy usually outweigh potential risks. Men with sleep apnea often have significantly lower testosterone levels, and treating sleep apnea can improve both hormones and mood. Also called androgen replacement therapy, this is a medical treatment your doctor may prescribe if blood tests show unusually low levels of testosterone. The following symptoms often point to imbalances in estrogen, progesterone, testosterone, thyroid hormones, or cortisol. Testosterone therapy may make sense for women who have low testosterone levels and symptoms that might be due to testosterone deficiency. A review of dozens of clinical trials showed that DHEA supplements do increase blood testosterone levels in men and women. In addition to these, having too-high testosterone levels put you at risk for health conditions including cancer, cardiac complications, and irritability (9).